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長效型的保康絲(柔沛)?

[日期:2008-11-16] 來源:網絡轉載  作者:佚名

有時會因為忙碌而忘記每天服用一次保康絲(柔沛)或是保列治(波斯卡),
甚至於吃了之後還會得了失憶症,忘了自己到底今天吃了沒?
試想,有沒有可能保康絲(柔沛)可以方便到一個月只吃一次,藥效就可以持續?


根據最近在中國長沙中南大學進行的一個研究顯示,長效型的Finasteride 1mg 在未來是可能的達到的。
這種長效型保康絲(柔沛)的的創意是希望藉由將成分包裹在藥中,隨著時間而逐漸發揮藥效,就可以免除每天服用一次的不便。在這個研究中,Finasteride被包裹在propylene carbonate maleate (PPCM)的膠囊中,實驗結果顯示,藥效會在5∼6週的時間逐漸釋放。雖然這只是初步的實驗,但因為已有其他長效型藥物的成功案例,所以長效型的 Finasteride,在未來還是可以預期的喔!

不過我在想,這長效型保康絲(柔沛)雖然方便,但一顆要多少錢?
如果吃一星期就有副作用產生,該怎麼辦? 留給科學家去傷腦筋吧!

資料出處:

Preparation of novel polymeric microspheres for controlled release of finasteride.
Int J Pharm. 2007 May 13. Peng D, Huang K, Liu Y, Liu S.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.

The utility of the novel polycarbonate, poly(propylene carbonate maleate) (PPCM) to encapsulate and control the release of finasteride, via microspheres, was investigated. The PPCM microspheres loaded with finasteride were elaborated by a simple oil-in-water (O/W) emulsion-solvent evaporation method. Various manufacturing parameters, including the concentration of polymer in dichloromethane (DCM) and the polymer:finasteride ratios were altered to optimize process variables during the microspheres production. The effects of these changes on the characteristics of the microspheres were examined. The structure and morphology were characterized by wide-angle X-ray diffraction (WXRD) and scanning electron microscopy (SEM). The results showed that the mean diameter of microspheres was approximately 2mum, and had both smooth and spherical surfaces. Greater encapsulation efficiency was obtained by increasing the ratios of polymer:finasteride and the concentration of PPCM in DCM. In vitro drug release of these microcapsules was performed in a pH 7.4 phosphate-buffered solution. The release profiles of finasteride from PPCM microcapsules were found to be biphasic with a burst release followed by a gradual release phase. A prolonged in vitro drug release profile was observed. After an initial burst, a continuous drug release was observed for up to 5-6 weeks.



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